Innate effector-memory T cell activation regulates post-thrombotic vein wall inflammation and thrombus resolution
F. Shahneh, N. Luther, M. Brähler, F. Krebs, S. Jäckel, P. Wenzel, K. Schäfer, C. Becker (Mainz, Germany)
Time: 08:00 - 09:15
Objective: This study investigated the functional role of T cells in venous thrombosis.
Methods: Deep vein thrombosis (DVT) was induced by 80% flow reduction in the inferior vena cava (IVC) of mice. T cell recruitment and inflammatory activity was followed by flow cytometry, histology and intrathrombotic gene expression in reporter strains and upon depletion of T cells over various time points after DVT.
Results: DVT recruits effector-memory T cells into the vein wall and thrombus. Recruited effector-memory T cells experience an immediate antigen-independent activation and produce IFN-gamma in situ. Effector-memory T cell-derived IFN-gamma determines neutrophil and monocyte recruitment and delays thrombus neovascularization and resolution.
Conclusion: Effector-memory T cells orchestrate the inflammatory response in venous thrombosis affecting thrombus resolution.